Stereoselective reduction of .ALPHA.-methyl-.BETA.-hydroxy ketones with zinc borohydride.

Highly chemoselective copper-catalyzed conjugate reduction of stereochemically labile alpha,beta-unsaturated amino ketones.

Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.

Alpha Hydroxy Acid (AHA) / Beta Hydroxy Acid (BHA)

AHAs act on both the epidermal and the dermal levels. When applied to the skin, AHAs stimulate the exfoliation of epidermal cells in the stratum corneum (s.c.) by interfering with the ionic bonding between these cells. This results in the sloughing off dull, rough skin and promotes cellular renewal. Initially used for treatment of hyperkeratosis and other skin conditions affecting s.c. turnover...

Synthetic Applications of Zinc Borohydride

Stereoselective Reduction of b-Hydroxy a-Ketoesters: A Concise Synthesis of anti-a,b-Dihydroxy Esters Stereoselective Reduction of b-Hydroxy a-Ketoesters

Sodium borohydride reduction of ketones, aldehydes and imines using PEG400 as catalyst without solvent

Aldehydes, ketones and imines were readily reduced by sodium borohydride, with the participation of a small amount of water, in good to excellent yields using PEG400 as catalyst in the absence of organic solvents.  2005 Society of Chemical Industry